Method 1: Disable Skype for Business via Skype Settings It is important to note that if you are using Office 365 Skype for Business, it is impossible to uninstall it from your computer unless you remove the reset of the Microsoft Office site.
And this article shows some working methods to disable or uninstall Skype for Business. Therefore, you can choose to disable or uninstall Skype for Business from your PC. But please don’t worry, as MiniTool shows effective ways to fix this issue. Tip: Sometimes, you may run into 100% Disk Usage on Windows 10 caused by the combination of Skype and Google Chrome browser settings.
